Concepedia

Selectivity Design

Selectivity Design is a strategic approach in drug design that specifically aims to develop therapeutic agents with preferential activity toward a particular biological target or subset of targets, thereby minimizing off-target effects and enhancing pharmacological precision.

232

Publications

12.1K

Citations

1.6K

Authors

345

Institutions

Publications per year

2017–2026

38

Parents

Children

Publications

232

A quantitative analysis of kinase inhibitor selectivity

Mazen W. Karaman, Sanna Herrgård, Daniel K. Treiber et al. · Nature Biotechnology · 2008 · 2.4K citations

, , +13

Structural Bioinformatics-Based Design of Selective, Irreversible Kinase Inhibitors

Michael S. Cohen, Chao Zhang, Kevan M. Shokat et al. · Science · 2005 · 508 citations · Full text

, , +15

Selectivity: A Key to Synthetic Efficiency

Barry M. Trost · Science · 1983 · 347 citations

, , +15

Application of the message-address concept in the design of highly potent and selective non-peptide .delta. opioid receptor antagonists

P. S. Portoghese, Marjia Sultana, Hiroshi Nagase et al. · Journal of Medicinal Chemistry · 1988 · 305 citations

, , +15

Design, synthesis, and evaluation of an improved enantioselective naproxen selector

William H. Pirkle, Christopher J. Welch, Bo Lamm · The Journal of Organic Chemistry · 1992 · 235 citations

, , +5

1–5 of 232

Authors

1.6K

  1. JB
    Jürgen Bajorath

    University of Bonn, Germany

    4 publications · 98 citations

    4

    h-index

  2. HN
    Hisao Nakai

    Ono Pharmaceutical (Japan), Japan

    4 publications · 67 citations

    4

    h-index

  3. MT
    Masaaki Toda

    Ono Pharmaceutical (Japan), Japan

    4 publications · 67 citations

    4

    h-index

  4. HK
    Hirosato Kondo

    Hokkaido University, Japan

    4 publications · 148 citations

    4

    h-index

  5. KK
    Kigen Kondo

    Ono Pharmaceutical (Japan), Japan

    4 publications · 67 citations

    4

    h-index

1–5 of 1.6K

Institutions

345

  1. University of Bonn

    Bonn, Germany

    7 h-index

    28 publications

    1.1K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    6 h-index

    17 publications

    1.3K citations

  3. Chinese Academy of Sciences

    Beijing, China

    4 h-index

    22 publications

    601 citations

  4. AstraZeneca (United Kingdom)

    Cambridge, United Kingdom

    4 h-index

    36 publications

    1.1K citations

  5. Ono Pharmaceutical (Japan)

    Osaka, Japan

    4 h-index

    48 publications

    819 citations

  6. Inserm

    Paris, France

    4 h-index

    21 publications

    1.6K citations

  7. University of California, San Francisco

    San Francisco, United States

    4 h-index

    21 publications

    2.6K citations

  8. University of Minnesota

    Minneapolis, United States

    3 h-index

    6 publications

    1.3K citations

1–8 of 345

Venues

  1. Journal of Medicinal Chemistry

    52 publications · 2.9K citations

    33

    h-index

  2. Bioorganic & Medicinal Chemistry Letters

    33 publications · 999 citations

    20

    h-index

  3. Bioorganic & Medicinal Chemistry

    9 publications · 312 citations

    9

    h-index

  4. Chemical Communications

    ChemComm · 6 publications · 200 citations

    6

    h-index

  5. ACS Medicinal Chemistry Letters

    5 publications · 165 citations

    5

    h-index

1–5