Concepedia

Comparative Binding Affinity Analysis

Comparative Binding Affinity Analysis is a computational or experimental methodology used in selectivity design to quantitatively evaluate and contrast the relative strengths of molecular interactions between a target biomolecule and multiple ligands, thereby identifying preferential binding partners based on differential affinity measurements.

19

Publications

1.6K

Citations

82

Authors

43

Institutions

Publications per year

2017–2026

2

Parents

Publications

19

Three-Dimensional Quantitative Structure−Activity Relationship Analyses Using Comparative Molecular Field Analysis and Comparative Molecular Similarity Indices Analysis To Elucidate Selectivity Differences of Inhibitors Binding to Trypsin, Thrombin, and Factor Xa

Markus Böhm, Jörg Stürzebecher, G. Klebe · Journal of Medicinal Chemistry · 1999 · 441 citations · Full text

, , +17

Prediction of Drug Binding Affinities by Comparative Binding Energy Analysis

Ángel R. Ortíz, M. Teresa Pisabarro, Federico Gago et al. · Journal of Medicinal Chemistry · 1995 · 266 citations

, , +13

Comparative ligand-binding analysis of ten human lipocalins

Daniel A. Breustedt, D.L. Schönfeld, Arne Skerra · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · 2006 · 155 citations

, , +11

On the prediction of binding properties of drug molecules by comparative molecular field analysis

G. Klebe, Ute Abraham · Journal of Medicinal Chemistry · 1993 · 115 citations

, , +13

Rational-Differential Design of Highly Specific Glycomimetic Ligands: Targeting DC-SIGN and Excluding Langerin Recognition

Vanessa Porkolab, E Chabrol, Norbert Varga et al. · ACS Chemical Biology · 2017 · 71 citations · Full text

, , +17

1–5 of 19

Authors

82

  1. FF
    Franck Fieschi

    Institut de Biologie Structurale, France

    1 publications · 71 citations

    1

    h-index

  2. KF
    Kimito Funatsu

    The University of Tokyo, Japan

    1 publications · 60 citations

    1

    h-index

  3. LW
    Leon W. Hoyer

    American Red Cross, United States

    1 publications · 38 citations

    1

    h-index

  4. JS
    Jörg Stürzebecher

    Friedrich Schiller University Jena, Germany

    1 publications · 441 citations

    1

    h-index

  5. MT
    Michel Thépaut

    Institut de Biologie Structurale, France

    1 publications · 71 citations

    1

    h-index

1–5 of 82

Institutions

43

  1. Centre National de la Recherche Scientifique

    Paris, France

    2 h-index

    11 publications

    611 citations

  2. RIKEN Advanced Science Institute

    Kobe, Japan

    1 h-index

    3 publications

    36 citations

  3. TU Dortmund University

    Dortmund, Germany

    1 h-index

    4 publications

    200 citations

  4. Commissariat à l'Énergie Atomique et aux Énergies Alternatives

    Paris, France

    1 h-index

    6 publications

    426 citations

  5. University of Hyderabad

    Hyderabad, India

    1 h-index

    3 publications

    150 citations

  6. Instituto de Investigaciones Químicas

    Seville, Spain

    1 h-index

    2 publications

    142 citations

  7. Forschungsverbund Berlin

    Berlin, Germany

    1 h-index

    1 publications

    31 citations

  8. Connecticut Children's Medical Center

    Hartford, United States

    1 h-index

    1 publications

    38 citations

1–8 of 43

Venues

  1. Journal of Medicinal Chemistry

    3 publications · 822 citations

    3

    h-index

  2. 1

    h-index

  3. ChemBioChem

    1 publications · 50 citations

    1

    h-index

  4. Physical Chemistry Chemical Physics

    PCCP · 1 publications · 44 citations

    1

    h-index

  5. Biochemistry

    1 publications · 23 citations

    1

    h-index

1–5