The discovery of novel imidazo[1,2-<i>a</i>]pyridine derivatives as covalent anticancer agents

Qin Song, Qianer Zhang, Xuejing Fan, Fatmata Kayaat, Ruicheng Lv, Jing Li, Yong Wang

Organic & Biomolecular Chemistry · 2024 · 14 citations · 25 references

Concepts

Abstract

Novel imidazo[1,2- a ]pyridine-based covalent inhibitors were synthesized via the scaffold hopping strategy. In vitro bioactivity assessment concluded that I-11 is a potent and selective KRAS G12C inhibitor.

References

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