Enhancing prime editor activity by directed protein evolution in yeast

Search-and-replace genome editing without double-strand breaks or donor DNA

Andrew V. Anzalone, Peyton B. Randolph, Jessie R. Davis et al. · Nature · 2019 · 4.4K citations · Full text

Genome Surgery, Medicine, Genetics +5

High-efficiency yeast transformation using the LiAc/SS carrier DNA/PEG method

R. Daniel Gietz, Robert H. Schiestl · Nature Protocols · 2007 · 2.8K citations

Molecular Biotechnology, Engineering, Natural Sciences +6

Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity

Michelle F. Richter, Kevin T. Zhao, Elliot O. Eton et al. · Nature Biotechnology · 2020 · 974 citations · Full text

Engineering, Biochemistry, Natural Sciences +9

Effect of Genome Size on AAV Vector Packaging

Zhijian Wu, Hongyan Yang, Peter Colosi · Molecular Therapy · 2009 · 935 citations · Full text

Viral Replication, Aav Vector Genomes, Vector Genomes +17

Enhanced prime editing systems by manipulating cellular determinants of editing outcomes

Peter J. Chen, Jeffrey A. Hussmann, Jun Yan et al. · Cell · 2021 · 746 citations · Full text

Off-target Effect, Engineering, Prime Editing +14