Tanja Rothgangl

In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels

Tanja Rothgangl, Melissa K. Dennis, Paulo J.C. Lin et al. · Nature Biotechnology · 2021 · 377 citations · Full text

Life Sciences, Genetics, Molecular Biology +17

In vivo prime editing of a metabolic liver disease in mice

Desirée Böck, Tanja Rothgangl, Lukas Villiger et al. · Science Translational Medicine · 2022 · 185 citations · Full text

Life Sciences, Biotechnology, Genetics +16

In vivo cytidine base editing of hepatocytes without detectable off-target mutations in RNA and DNA

Lukas Villiger, Tanja Rothgangl, Dominik Witzigmann et al. · Nature Biomedical Engineering · 2021 · 102 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +11

Loss of Rnf31 and Vps4b sensitizes pancreatic cancer to T cell-mediated killing

Nina Frey, Luigi Tortola, David Egli et al. · Nature Communications · 2022 · 61 citations · Full text

Life Sciences, Immunology, Oncology +17

Continuous directed evolution of a compact CjCas9 variant with broad PAM compatibility

Lukas Schmidheini, Nicolas Mathis, Kim Fabiano Marquart et al. · Nature Chemical Biology · 2023 · 45 citations · Full text

Life Sciences, Bioinformatics, Molecular Genetics +10