Lukas Villiger

Treatment of a metabolic liver disease by in vivo genome base editing in adult mice

Lukas Villiger, Hiu Man Grisch‐Chan, Helen Lindsay et al. · Nature Medicine · 2018 · 440 citations

Life Sciences, Genetics, Molecular Genetics +15

Drag-and-drop genome insertion of large sequences without double-strand DNA cleavage using CRISPR-directed integrases

Matthew T. N. Yarnall, Eleonora Ioannidi, Cian Schmitt-Ulms et al. · Nature Biotechnology · 2022 · 429 citations · Full text

Life Sciences, Genetics, Molecular Biology +15

In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels

Tanja Rothgangl, Melissa K. Dennis, Paulo J.C. Lin et al. · Nature Biotechnology · 2021 · 377 citations · Full text

Life Sciences, Genetics, Molecular Biology +17

Growth of Epithelial Organoids in a Defined Hydrogel

Nicolas Broguière, Luca Isenmann, Christian Hirt et al. · Advanced Materials · 2018 · 283 citations · Full text

Engineering, Bioengineering, Biomedical Engineering +17

Genome-Scale CRISPR Screening in Human Intestinal Organoids Identifies Drivers of TGF-β Resistance

Till Ringel, Nina Frey, Femke Ringnalda et al. · Cell stem cell · 2020 · 199 citations · Full text

Life Sciences, Genetics, Molecular Biology +16