Dominik Witzigmann

The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs

Akin Akinc, Martin A. Maier, Muthiah Manoharan et al. · Nature Nanotechnology · 2019 · 1.6K citations · Full text

Pharmacy, Molecular Pharmaceutics, Pharmacology +16

On the role of helper lipids in lipid nanoparticle formulations of siRNA

Jayesh A. Kulkarni, Dominik Witzigmann, Jerry Leung et al. · Nanoscale · 2019 · 383 citations

Pharmacy, Molecular Pharmaceutics, Pharmaceutics +17

In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels

Tanja Rothgangl, Melissa K. Dennis, Paulo J.C. Lin et al. · Nature Biotechnology · 2021 · 377 citations · Full text

Life Sciences, Genetics, Molecular Biology +17

Induction of Bleb Structures in Lipid Nanoparticle Formulations of mRNA Leads to Improved Transfection Potency

Miffy H. Y. Cheng, Jerry Leung, Yao Zhang et al. · Advanced Materials · 2023 · 210 citations · Full text

Pharmacy, Biochemistry, Molecular Biology +17

Anionic Lipid Nanoparticles Preferentially Deliver mRNA to the Hepatic Reticuloendothelial System

Roy Pattipeiluhu, Gabriela Arias‐Alpizar, Genc Basha et al. · Advanced Materials · 2022 · 181 citations · Full text

Pharmacy, Pharmaceutics, Pharmacology +17