Dominik Witzigmann

The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs

Akin Akinc, Martin A. Maier, Muthiah Manoharan et al. · Nature Nanotechnology · 2019 · 1.5K citations · Full text

Nanomedicine, Engineering, Clinical Translation +9

On the role of helper lipids in lipid nanoparticle formulations of siRNA

Jayesh A. Kulkarni, Dominik Witzigmann, Jerry Leung et al. · Nanoscale · 2019 · 359 citations

In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels

Tanja Rothgangl, Melissa K. Dennis, Paulo J.C. Lin et al. · Nature Biotechnology · 2021 · 352 citations · Full text

Induction of Bleb Structures in Lipid Nanoparticle Formulations of mRNA Leads to Improved Transfection Potency

Miffy H. Y. Cheng, Jerry Leung, Yao Zhang et al. · Advanced Materials · 2023 · 184 citations · Full text

Lipid Preparation, Nanomedicine, Improved Transfection Potency +14

Anionic Lipid Nanoparticles Preferentially Deliver mRNA to the Hepatic Reticuloendothelial System

Roy Pattipeiluhu, Gabriela Arias‐Alpizar, Genc Basha et al. · Advanced Materials · 2022 · 167 citations · Full text

Nanoparticles, Nanomedicine, Hepatic Reticuloendothelial System +15