Concepedia

Combined MEK and STAT3 Inhibition Uncovers Stromal Plasticity by Enriching for Cancer-Associated Fibroblasts With Mesenchymal Stem Cell-Like Features to Overcome Immunotherapy Resistance in Pancreatic Cancer

Jashodeep Datta, Xizi Dai, Anna Bianchi, Iago De Castro Silva, Siddharth Mehra, Vanessa T. Garrido, Purushottam Lamichhane, Samara P. Singh, Zhiqun Zhou, Austin R. Dosch,

Gastroenterology · 2022 · 163 citations · 43 references

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43

Efficacy of Pembrolizumab in Patients With Noncolorectal High Microsatellite Instability/Mismatch Repair–Deficient Cancer: Results From the Phase II KEYNOTE-158 Study

Aurélien Marabelle, Dung T. Le, Paolo A. Ascierto et al. · Journal of Clinical Oncology · 2019 · 3K citations · Full text

, , +17

Tumor and Microenvironment Evolution during Immunotherapy with Nivolumab

Nadeem Riaz, Jonathan J. Havel, Vladimir Makarov et al. · Cell · 2017 · 2.6K citations · Full text

, , +12

Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer

Daniel Öhlund, Abram Handly-Santana, Giulia Biffi et al. · The Journal of Experimental Medicine · 2017 · 2.5K citations · Full text

, , +17

Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts

Ela Elyada, Mohan Bolisetty, Pasquale Laise et al. · Cancer Discovery · 2019 · 2.1K citations · Full text

, , +17

Single-cell mRNA quantification and differential analysis with Census

Xiaojie Qiu, Andrew J. Hill, Jonathan S. Packer et al. · Nature Methods · 2017 · 2.1K citations

, , +14