Iago De Castro Silva

Combined MEK and STAT3 Inhibition Uncovers Stromal Plasticity by Enriching for Cancer-Associated Fibroblasts With Mesenchymal Stem Cell-Like Features to Overcome Immunotherapy Resistance in Pancreatic Cancer

Jashodeep Datta, Xizi Dai, Anna Bianchi et al. · Gastroenterology · 2022 · 163 citations · Full text

Medicine, Cell Biology, Oncology +17

Cell-Autonomous Cxcl1 Sustains Tolerogenic Circuitries and Stromal Inflammation via Neutrophil-Derived TNF in Pancreatic Cancer

Anna Bianchi, Iago De Castro Silva, Nilesh Deshpande et al. · Cancer Discovery · 2023 · 128 citations · Full text

Medicine, Immunology, Oncology +17

Targeting Tumor–Stromal IL6/STAT3 Signaling through IL1 Receptor Inhibition in Pancreatic Cancer

Austin R. Dosch, Samara P. Singh, Xizi Dai et al. · Molecular Cancer Therapeutics · 2021 · 54 citations · Full text

Medicine, Cancer Biology, Oncology +17

Distinct mechanisms of innate and adaptive immune regulation underlie poor oncologic outcomes associated with KRAS-TP53 co-alteration in pancreatic cancer

Jashodeep Datta, Anna Bianchi, Iago De Castro Silva et al. · Oncogene · 2022 · 46 citations

Life Sciences, Immunology, Oncology +13

Neutrophil-mediated fibroblast-tumor cell il-6/stat-3 signaling underlies the association between neutrophil-to-lymphocyte ratio dynamics and chemotherapy response in localized pancreatic cancer: A hybrid clinical-preclinical study

Iago De Castro Silva, Anna Bianchi, Nilesh Deshpande et al. · eLife · 2022 · 45 citations · Full text

Medicine, Cancer Biology, Oncology +15