Concepedia

Tumor-stroma Interactions

Tumor-Stroma Interactions is a biological process denoting the dynamic and reciprocal communication between tumor cells and the surrounding stromal components of the tumor microenvironment, including fibroblasts, immune cells, endothelial cells, and extracellular matrix, that collectively influence tumor progression, invasion, and therapeutic response.

8.8K

Publications

673.6K

Citations

48.9K

Authors

5.6K

Institutions

Publications per year

2017–2026

2.4K

Variants

Tumor-stroma Crosstalk

Parents

Children

Publications

8.8K

Efficacy and Safety of Imatinib Mesylate in Advanced Gastrointestinal Stromal Tumors

George D. Demetri, Margaret von Mehren, Charles D. Blanke et al. · New England Journal of Medicine · 2002 · 4.4K citations · Full text

, , +14

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

Kandice R. Levental, Hongmei Yu, Laura Kass et al. · Cell · 2009 · 4K citations · Full text

, , +14

Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion

Akira Orimo, Piyush B. Gupta, Dennis C. Sgroi et al. · Cell · 2005 · 3.7K citations · Full text

, , +14

Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN

Zvi G. Fridlender, Jing Sun, Samuel Kim et al. · Cancer Cell · 2009 · 3.3K citations · Full text

, , +12

Mesenchymal stem cells within tumour stroma promote breast cancer metastasis

Antoine E. Karnoub, Ajeeta B. Dash, Annie P. Vo et al. · Nature · 2007 · 3.2K citations

, , +12

1–5 of 8.8K

Authors

48.9K

  1. DR
    David R. Rowley

    Baylor College of Medicine, United States

    28 publications · 4K citations

    24

    h-index

  2. WE
    Wilma E. Mesker

    Leiden University Medical Center, Netherlands

    31 publications · 2.7K citations

    23

    h-index

  3. MP
    Michael P. Lisanti

    Albert Einstein College of Medicine, United States

    25 publications · 4.3K citations

    23

    h-index

  4. BP
    Bryan P. Toole

    Tufts University, United States

    22 publications · 3.4K citations

    22

    h-index

  5. GD
    George D. Demetri

    Dana-Farber Cancer Institute, United States

    24 publications · 9.2K citations

    22

    h-index

1–5 of 48.9K

Institutions

5.6K

  1. Harvard University

    Cambridge, United States

    98 h-index

    998 publications

    164K citations

  2. The University of Texas MD Anderson Cancer Center

    Houston, United States

    83 h-index

    926 publications

    119.7K citations

  3. Inserm

    Paris, France

    81 h-index

    1.3K publications

    145.4K citations

  4. Dana-Farber Cancer Institute

    Boston, United States

    60 h-index

    523 publications

    118K citations

  5. Massachusetts General Hospital

    Boston, United States

    60 h-index

    480 publications

    106.2K citations

  6. Heidelberg University

    Heidelberg, Germany

    60 h-index

    585 publications

    54.9K citations

  7. Brigham and Women's Hospital

    Boston, United States

    54 h-index

    451 publications

    61.4K citations

  8. University of California, San Francisco

    San Francisco, United States

    54 h-index

    238 publications

    70.3K citations

1–8 of 5.6K

Venues

  1. PubMed

    Repository · 689 publications · 53.1K citations

    118

    h-index

  2. Cancer Research

    289 publications · 42.1K citations

    115

    h-index

  3. International Journal of Cancer

    245 publications · 17.3K citations

    78

    h-index

  4. Oncogene

    134 publications · 13.1K citations

    67

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 78 publications · 17.5K citations

    65

    h-index

1–5