Tumour rejection by gene transfer of 4-1BB ligand into a CD80+ murine squamous cell carcinoma and the requirements of co-stimulatory molecules on tumour and host cells

Tumor Rejection After Direct Costimulation of CD8 ⁺ T Cells by B7-Transfected Melanoma Cells

Sarah E. Townsend, James P. Allison · Science · 1993 · 1.1K citations

Life Sciences, Immunology, Oncology +17

Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4

Lieping Chen, Stephanie Ashe, William Brady et al. · Cell · 1992 · 1.1K citations

Life Sciences, Immunology, Oncology +16

Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors

Ignacio Melero, Walter W. Shuford, S A Newby et al. · Nature Medicine · 1997 · 891 citations

Life Sciences, Immunology, Oncology +14

4-1BB Costimulatory Signals Preferentially Induce CD8+ T Cell Proliferation and Lead to the Amplification In Vivo of Cytotoxic T Cell Responses

Walter W. Shuford, Kerry Klussman, Douglas D. Tritchler et al. · The Journal of Experimental Medicine · 1997 · 792 citations · Full text

Life Sciences, Cell Biology, Immunology +17

Tumor immunogenicity determines the effect of B7 costimulation on T cell-mediated tumor immunity.

Lieping Chen, Patrick O. McGowan, S Ashe et al. · The Journal of Experimental Medicine · 1994 · 470 citations · Full text

Life Sciences, Immunology, Oncology +15