Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

Suzanne L. Topalian, F. Stephen Hodi, Julie R. Brahmer, +27

New England Journal of Medicine

Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

Tyler J. Curiel, George Coukos, Linhua Zou, +18

Nature Medicine

Cancer ImmunosurveillanceSpecific RecruitmentT-regulatory CellImmune RegulationImmunology +7

Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion

Haidong Dong, Scott E. Strome, Diva R. Salomão, +10

Nature Medicine

Immune EvasionCancer ImmunosurveillanceT-cell ApoptosisImmunologyImmunoediting +5

Phase I Study of Single-Agent Anti–Programmed Death-1 (MDX-1106) in Refractory Solid Tumors: Safety, Clinical Activity, Pharmacodynamics, and Immunologic Correlates

Julie R. Brahmer, Charles G. Drake, Ira Wollner, +17

Journal of Clinical Oncology

B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion

Haidong Dong, Gefeng Zhu, Koji Tamada, +1

Nature Medicine

InflammationCytokineB7 FamilyAutoimmune DiseaseLymphocyte Development +11

Association of PD-1, PD-1 Ligands, and Other Features of the Tumor Immune Microenvironment with Response to Anti–PD-1 Therapy

Janis M. Taube, Alison Klein, Julie R. Brahmer, +7

Clinical Cancer Research

Colocalization of Inflammatory Response with B7-H1 Expression in Human Melanocytic Lesions Supports an Adaptive Resistance Mechanism of Immune Escape

Janis M. Taube, Robert A. Anders, Geoffrey D. Young, +8

Science Translational Medicine

ImmunologyImmune RegulationImmunoeditingImmunologic MechanismImmunotherapeutics +23

Blockade of B7-H1 improves myeloid dendritic cell–mediated antitumor immunity

Tyler J. Curiel, Shuang Wei, Haidong Dong, +19

Nature Medicine

Cancer ImmunosurveillanceImmunologyTumor ImmunityT Cell ImmunityDendritic Cell Biology +3

Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4

Lieping Chen, Stephanie Ashe, William Brady, +5

Cell

Immunological MemoryCancer ImmunosurveillanceAutoimmune DiseaseB7 CounterreceptorImmunology +8

B7-H3: A costimulatory molecule for T cell activation and IFN-γ production

Andrei I. Chapoval, Jian Ni, Julie S. Lau, +8

Nature Immunology

T Cell ActivationAdaptive Immune SystemImmune Cell DevelopmentImmune RegulationImmunology +8