Concepedia

Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages

Marah C. Runtsch, Stefano Angiari, Alexander Hooftman, Ridhima Wadhwa, Yanling Zhang, Yunan Zheng, Joseph S. Spina, Melanie C. Ruzek, M.A. Argiriadi, Anne F. McGettrick,

Cell Metabolism · 2022 · 318 citations · 44 references

DOI

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References

44

Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization

Abhishek Jha, Stanley Ching‐Cheng Huang, Alexey Sergushichev et al. · Immunity · 2015 · 2K citations · Full text

, , +17

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

Evanna L. Mills, Dylan G. Ryan, Hiran A. Prag et al. · Nature · 2018 · 1.8K citations

, , +12

Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription

Eri Kobayashi, Takafumi Suzuki, Ryo Funayama et al. · Nature Communications · 2016 · 1.8K citations · Full text

, , +17

Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation

Vicky Lampropoulou, Alexey Sergushichev, Monika Bambousková et al. · Cell Metabolism · 2016 · 1.5K citations · Full text

, , +16

α-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming

Haiping Wang, Xiaoyun Li, Tung Chao et al. · Nature Immunology · 2017 · 1.2K citations · Full text

, , +13