Anne F. McGettrick

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

Gillian M. Tannahill, Annie M. Curtis, Juraj Adamik et al. · Nature · 2013 · 4K citations · Full text

Life Sciences, Immunology, Molecular Medicine +12

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

Evanna L. Mills, Dylan G. Ryan, Hiran A. Prag et al. · Nature · 2018 · 1.8K citations

Life Sciences, Biochemistry, Cell Biology +12

The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation

Alexander Hooftman, Stefano Angiari, Svenja Hester et al. · Cell Metabolism · 2020 · 588 citations · Full text

Life Sciences, Cell Biology, Immunology +14

Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages

Marah C. Runtsch, Stefano Angiari, Alexander Hooftman et al. · Cell Metabolism · 2022 · 318 citations

Life Sciences, Cell Biology, Immunology +14

Circadian control of innate immunity in macrophages by miR-155 targeting <i>Bmal1</i>

Annie M. Curtis, Caio T. Fagundes, Guangrui Yang et al. · Proceedings of the National Academy of Sciences · 2015 · 306 citations · Full text

Life Sciences, Immunology, Physiology +17