Marah C. Runtsch

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

Evanna L. Mills, Dylan G. Ryan, Hiran A. Prag et al. · Nature · 2018 · 1.7K citations · Full text

Inflammation, Reductive Stress, Anti-inflammatory +10

Exosome-delivered microRNAs modulate the inflammatory response to endotoxin

Margaret Alexander, Ruozhen Hu, Marah C. Runtsch et al. · Nature Communications · 2015 · 745 citations · Full text

The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation

Alexander Hooftman, Stefano Angiari, Svenja Hester et al. · Cell Metabolism · 2020 · 542 citations · Full text

Inflammation, Anti-inflammatory, Signal Transduction +12

Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4+ T Cell Pathogenicity and Suppresses Autoimmunity

Stefano Angiari, Marah C. Runtsch, Caroline E. Sutton et al. · Cell Metabolism · 2019 · 306 citations · Full text

Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages

Marah C. Runtsch, Stefano Angiari, Alexander Hooftman et al. · Cell Metabolism · 2022 · 295 citations

Inflammation, Itaconate Derivatives, Alternative Activation +13