Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation

Vicky Lampropoulou, Alexey Sergushichev, Monika Bambousková, +15

Cell Metabolism

InflammationSuccinate DehydrogenaseMacrophage Metabolic RemodelingAnti-inflammatoryItaconate Links Inhibition +10

Electrophilic properties of itaconate and derivatives regulate the IκBζ–ATF3 inflammatory axis

Monika Bambousková, Laurent Gorvel, Vicky Lampropoulou, +28

Nature

InflammationCytokineInflammatory DiseaseSignal TransductionImmunology +10

Comprehensive Profiling of an Aging Immune System Reveals Clonal GZMK+ CD8+ T Cells as Conserved Hallmark of Inflammaging

Denis A. Mogilenko, Oleg Shpynov, Prabhakar S. Andhey, +15

Immunity

InflammationAutoimmune DiseaseAdaptive Immune SystemComprehensive ProfilingMedicine +10

Comparative evaluation of itaconate and its derivatives reveals divergent inflammasome and type I interferon regulation in macrophages

Amanda Swain, Monika Bambousková, Hyeryun Kim, +8

Nature Metabolism

InflammationCytokineAutoimmune DiseaseImmunologyImmunologic Mechanism +9

Itaconate confers tolerance to late NLRP3 inflammasome activation

Monika Bambousková, Lucie Potůčková, Tomáš Paulenda, +19

Cell Reports

Complete deconvolution of cellular mixtures based on linearity of transcriptional signatures

Konstantin Zaitsev, Monika Bambousková, Amanda Swain, +1

Nature Communications

Mycobacterium tuberculosis carrying a rifampicin drug resistance mutation reprograms macrophage metabolism through cell wall lipid changes

Nicole C. Howard, Nancy D. Marín, Mushtaq Ahmed, +18

Nature Microbiology

Medical MicrobiologyPulmonary TuberculosisHealth SciencesMycobacterium TuberculosisImmunology +8

Liver ACOX1 regulates levels of circulating lipids that promote metabolic health through adipose remodeling

Dongliang Lu, Anyuan He, Min Tan, +9

Nature Communications

Interleukin-17 limits hypoxia-inducible factor 1α and development of hypoxic granulomas during tuberculosis

Racquel Domingo-Gonzalez, Shibali Das, Kristin Griffiths, +27

JCI Insight

Microbial PathogensImmunologyImmune RegulationPathologyInnate Immunity +17

Rapid and sensitive detection of cytokines using functionalized gold nanoparticle-based immuno-PCR, comparison with immuno-PCR and ELISA

Lucie Potůčková, Filip Franko, Monika Bambousková, +1

Journal of Immunological Methods

NanoparticlesSensitive DetectionImmunocytochemical TechniqueEngineeringImmunology +17