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Discovery of a potent and highly selective inhibitor of ataxia telangiectasia mutated and Rad3-Related (ATR) kinase: Structural activity relationship and antitumor activity both in vitro and in vivo

Huachao Bin, Pei Chen, Ming Wu, Falu Wang, Guifeng Lin, Shulei Pan, Jingming Liu, Bo Mu, Jinshan Nan, Qiao Huang,

European Journal of Medicinal Chemistry · 2022 · 26 citations · 29 references

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29

A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling

Zachary A. Knight, Beatriz González, Morri E. Feldman et al. · Cell · 2006 · 1.2K citations · Full text

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The Identification of 2-(1<i>H</i>-Indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-<i>d</i>]pyrimidine (GDC-0941) as a Potent, Selective, Orally Bioavailable Inhibitor of Class I PI3 Kinase for the Treatment of Cancer

Adrian Folkes, Khatereh Ahmadi, W. Alderton et al. · Journal of Medicinal Chemistry · 2008 · 746 citations · Full text

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Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin.

Jann N. Sarkaria, Randal S. Tibbetts, Ericka C. Busby et al. · PubMed · 1998 · 527 citations

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A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations

Luis Toledo, Matilde Murga, Rafal Zur et al. · Nature Structural & Molecular Biology · 2011 · 461 citations · Full text

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GENETICS OF NATURAL POPULATIONS. XIII. RECOMBINATION AND VARIABILITY IN POPULATIONS OF DROSOPHILA PSEUDOOBSCURA

Th. Dobzhansky · Genetics · 1946 · 431 citations · Full text

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