Jinshan Nan

A new generation Mpro inhibitor with potent activity against SARS-CoV-2 Omicron variants

Chong Huang, Huiping Shuai, Jingxin Qiao et al. · Signal Transduction and Targeted Therapy · 2023 · 81 citations · Full text

Life Sciences, Pharmacokinetics, Pharmacology +15

Discovery of a novel and potent inhibitor with differential species-specific effects against NLRP3 and AIM2 inflammasome-dependent pyroptosis

Jiao Yan, Jinshan Nan, Bo Mu et al. · European Journal of Medicinal Chemistry · 2022 · 54 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12

Discovery and structure-activity relationship studies of 1-aryl-1H-naphtho[2,3-d][1,2,3]triazole-4,9-dione derivatives as potent dual inhibitors of indoleamine 2,3-dioxygenase 1 (IDO1) and trytophan 2,3-dioxygenase (TDO)

Shulei Pan, Qiusheng Wang, Yanlin Wang et al. · European Journal of Medicinal Chemistry · 2020 · 34 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Structural Optimization and Structure–Activity Relationship Studies of 6,6-Dimethyl-4-(phenylamino)-6<i>H</i>-pyrimido[5,4-<i>b</i>][1,4]oxazin-7(8<i>H</i>)-one Derivatives as A New Class of Potent Inhibitors of Pan-Trk and Their Drug-Resistant Mutants

Shulei Pan, Liting Zhang, Xinling Luo et al. · Journal of Medicinal Chemistry · 2022 · 26 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Discovery of a potent and highly selective inhibitor of ataxia telangiectasia mutated and Rad3-Related (ATR) kinase: Structural activity relationship and antitumor activity both in vitro and in vivo

Huachao Bin, Pei Chen, Ming Wu et al. · European Journal of Medicinal Chemistry · 2022 · 26 citations · Full text

Pharmacy, Medicinal Chemistry, Oncology +12