Concepedia

Atm Activation

ATM Activation is a molecular signaling event, belonging to the class of DNA damage response mechanisms, wherein the ataxia telangiectasia mutated (ATM) kinase is induced into an active conformational state specifically in response to double-strand breaks, thereby initiating downstream pathways that coordinate cell cycle arrest, DNA repair, and genomic stability.

694

Publications

71.5K

Citations

4.2K

Authors

1.1K

Institutions

Publications per year

2017–2026

145

Variants

Atm Kinase Activation

Parents

Publications

694

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

Christopher J. Bakkenist, Michael B. Kastan · Nature · 2003 · 3.4K citations

, , +15

Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53

Christine E. Canman, Dae‐Sik Lim, Karlene A. Cimprich et al. · Science · 1998 · 2.1K citations

, , +15

Enhanced Phosphorylation of p53 by ATM in Response to DNA Damage

Sharon Banin, Lilach Moyal, Sheau-Yann Shieh et al. · Science · 1998 · 1.8K citations

, , +15

Atm-Deficient Mice: A Paradigm of Ataxia Telangiectasia

Carrolee Barlow, Shinji Hirotsune, Richard Paylor et al. · Cell · 1996 · 1.5K citations · Full text

, , +12

ATM Activation by DNA Double-Strand Breaks Through the Mre11-Rad50-Nbs1 Complex

Ji‐Hoon Lee, Tanya T. Paull · Science · 2005 · 1.4K citations

, , +17

1–5 of 694

Authors

4.2K

  1. MF
    Martin F. Lavin

    The University of Queensland, Australia

    24 publications · 4.3K citations

    22

    h-index

  2. YS
    Yosef Shiloh

    Tel Aviv University, Israel

    21 publications · 8.3K citations

    21

    h-index

  3. ZD
    Zbigniew Darżynkiewicz

    New York Medical College, United States

    20 publications · 1.1K citations

    19

    h-index

  4. FT
    Frank Traganos

    New York Medical College, United States

    17 publications · 1K citations

    17

    h-index

  5. MB
    Michael B. Kastan

    St. Jude Children's Research Hospital, United States

    18 publications · 9.4K citations

    17

    h-index

1–5 of 4.2K

Institutions

1.1K

  1. QIMR Berghofer Medical Research Institute

    Brisbane, Australia

    27 h-index

    106 publications

    20.9K citations

  2. Tel Aviv University

    Tel Aviv, Israel

    26 h-index

    93 publications

    48.8K citations

  3. Harvard University

    Cambridge, United States

    23 h-index

    105 publications

    13.9K citations

  4. National Institutes of Health

    Bethesda, United States

    21 h-index

    83 publications

    11.6K citations

  5. New York Medical College

    Valhalla, United States

    21 h-index

    78 publications

    4.1K citations

  6. Cancer Research UK

    London, United Kingdom

    20 h-index

    58 publications

    6.9K citations

  7. The University of Queensland

    Brisbane, Australia

    18 h-index

    53 publications

    11K citations

  8. Inserm

    Paris, France

    18 h-index

    111 publications

    6.7K citations

1–8 of 1.1K

Venues

  1. Journal of Biological Chemistry

    JBC · 53 publications · 5.8K citations

    43

    h-index

  2. Oncogene

    30 publications · 2.3K citations

    25

    h-index

  3. Cell Cycle

    22 publications · 1.7K citations

    19

    h-index

  4. Cancer Research

    22 publications · 1.5K citations

    17

    h-index

  5. PLoS ONE

    17 publications · 875 citations

    15

    h-index

1–5