Christopher J. Bakkenist

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

Christopher J. Bakkenist, Michael B. Kastan · Nature · 2003 · 3.4K citations

Chromatin, Genome Instability, Dna Damage +6

Phosphorylation of SMC1 is a critical downstream event in the ATM–NBS1–BRCA1 pathway

Risa Kitagawa, Christopher J. Bakkenist, Peter J. McKinnon et al. · Genes & Development · 2004 · 538 citations · Full text

Dna Damage, Genetics, Molecular Biology +22

The Telomeric Protein TRF2 Binds the ATM Kinase and Can Inhibit the ATM-Dependent DNA Damage Response

Jan Karlseder, Kristina Hoke, Olga K. Mirzoeva et al. · PLoS Biology · 2004 · 393 citations · Full text

Chromatin, Genome Instability, Dna Damage +13

The orally active and bioavailable ATR kinase inhibitor AZD6738 potentiates the anti-tumor effects of cisplatin to resolve ATM-deficient non-small cell lung cancer<i>in vivo</i>

Frank P. Vendetti, Alan Lau, Sandra Schamus et al. · Oncotarget · 2015 · 235 citations · Full text

ATR kinase inhibitor AZD6738 potentiates CD8+ T cell–dependent antitumor activity following radiation

Frank P. Vendetti, Pooja Karukonda, David A. Clump et al. · Journal of Clinical Investigation · 2018 · 202 citations · Full text