METTL3-mediated m6A modification of ATG7 regulates autophagy-GATA4 axis to promote cellular senescence and osteoarthritis progression

N6-methyladenosine-dependent regulation of messenger RNA stability

Xiao Wang, Zhike Lu, Adrian Gomez-Nguyen et al. · Nature · 2013 · 4.8K citations

Life Sciences, Biochemistry, Molecular Biology +14

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

Ok Hee Jeon, Chaekyu Kim, Remi-Martin Laberge et al. · Nature Medicine · 2017 · 1.5K citations · Full text

Dentistry, Cell Biology, Orthopaedic Surgery +17

The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells

Ly Vu, Brian F. Pickering, Yuanming Cheng et al. · Nature Medicine · 2017 · 1.3K citations · Full text

Life Sciences, Genetics, Molecular Biology +12

Perturbation of m6A Writers Reveals Two Distinct Classes of mRNA Methylation at Internal and 5′ Sites

Schraga Schwartz, Maxwell R. Mumbach, Marko Jovanović et al. · Cell Reports · 2014 · 1.3K citations · Full text

Life Sciences, Biology, Molecular Biology +15

The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4

Chanhee Kang, Qikai Xu, Timothy D. Martin et al. · Science · 2015 · 980 citations · Full text

Education, Cell Biology, Molecular Biology +17