Cartilage Breakdown

Cartilage Breakdown is a pathophysiological process characterized by the progressive degradation and loss of extracellular matrix components in articular cartilage, primarily due to enzymatic activity and biomechanical stress, within the context of temporomandibular joint osteoarthritis.

7.1K

Publications

415K

Citations

25.8K

Authors

Institutions

Publications per year

2017–2026

2.2K

Parents

Temporomandibular Joint Osteoarthritis

Children

Cartilage Breakdown PathophysiologyCartilage Degradation MechanismsCartilage Extracellular Matrix HomeostasisCartilage FibrillationCartilage MineralizationCartilage Protease ActivityCartilage Proteoglycan SynthesisCartilage Repair FailureCartilage Surface FissuringCartilage Thickness Loss

Publications

7.1K

Biochemical and Metabolic Abnormalities in Articular Cartilage from Osteo-Arthritic Human Hips

Henry J. Mankin, HOWARD DORFMAN, Louis Lippiello et al. · Journal of Bone and Joint Surgery · 1971 · 2K citations

Medicine, Orthopaedic Surgery, Orthopedic Surgery +17

MMP-9/Gelatinase B Is a Key Regulator of Growth Plate Angiogenesis and Apoptosis of Hypertrophic Chondrocytes

Thiennu H. Vu, J. Michael Shipley, Gabriele Bergers et al. · Cell · 1998 · 1.8K citations · Full text

Life Sciences, Cell Biology, Pathology +11

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

Ok Hee Jeon, Chaekyu Kim, Remi-Martin Laberge et al. · Nature Medicine · 2017 · 1.5K citations · Full text

Dentistry, Cell Biology, Orthopaedic Surgery +17

Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis

S.S. Glasson, Roger Askew, Barbara Sheppard et al. · Nature · 2005 · 1.3K citations

Dentistry, Genetics, Molecular Genetics +14

A Triphasic Theory for the Swelling and Deformation Behaviors of Articular Cartilage

W. M. Lai, Jie Hou, Van C. Mow · Journal of Biomechanical Engineering · 1991 · 1.1K citations

Natural Sciences, Biophysics, Chemistry +16

1–5 of 7.1K

Authors

25.8K

JM
Johanne Martel‐Pelletier
Université de Montréal, Canada
75 publications · 7.3K citations
44
h-index
WB
Wim B. van den Berg
Radboud University Nijmegen, Netherlands
69 publications · 6.1K citations
44
h-index
AR
A. Robin Poole
McGill University, Canada
56 publications · 6.7K citations
41
h-index
PJ
Peter J. Roughley
Shriners Hospitals for Children - Canada, Canada
45 publications · 4.5K citations
39
h-index
MK
M.A. Karsdal
Nordic Bioscience (Denmark), Denmark
59 publications · 3.4K citations
37
h-index

1–5 of 25.8K

Institutions

1–8 of 4K

Venues

Arthritis & Rheumatism
434 publications · 46.2K citations
122
h-index
Osteoarthritis and Cartilage
561 publications · 37.2K citations
102
h-index
Annals of the Rheumatic Diseases
ARD · 187 publications · 18.9K citations
80
h-index
PubMed
Repository · 491 publications · 21.6K citations
73
h-index
Arthritis Research & Therapy
184 publications · 14.4K citations
72
h-index

1–5