Publication | Open Access

Structure-activity relationship study of THZ531 derivatives enables the discovery of BSJ-01-175 as a dual CDK12/13 covalent inhibitor with efficacy in Ewing sarcoma

Ewing SarcomaThz531 DerivativesMedicineStructure-activity Relationship StudyMolecular BiologyTumor TargetingAnti-cancer AgentTumor SuppressorCancer BiologyCell BiologyNovel TherapyCancer Research