Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules

Behnam Nabet, Fleur M. Ferguson, Bo Kyung A. Seong, +10

Nature Communications

STAG2 loss rewires oncogenic and developmental programs to promote metastasis in Ewing sarcoma

Biniam Adane, Gabriela Alexe, Bo Kyung A. Seong, +25

Cancer Cell

Ewing SarcomaMedicinePathologyCancer GeneticsStag2 Loss +5

TRIM8 modulates the EWS/FLI oncoprotein to promote survival in Ewing sarcoma

Bo Kyung A. Seong, Neekesh V. Dharia, Shan Lin, +18

Cancer Cell

SATB2 enhances migration and invasion in osteosarcoma by regulating genes involved in cytoskeletal organization

Bo Kyung A. Seong, Joanne Lau, Teresa Adderley, +6

Oncogene

MedicineMolecular BiologyCell MigrationCancer GeneticsCancer Biology +3

Structure-activity relationship study of THZ531 derivatives enables the discovery of BSJ-01-175 as a dual CDK12/13 covalent inhibitor with efficacy in Ewing sarcoma

Baishan Jiang, Jie Jiang, Ines H. Kaltheuner, +13

European Journal of Medicinal Chemistry

Ewing SarcomaThz531 DerivativesMedicineStructure-activity Relationship StudyMolecular Biology +7

Biology and Therapy of Dominant Fusion Oncoproteins Involving Transcription Factor and Chromatin Regulators in Sarcomas

Jennifer A. Perry, Bo Kyung A. Seong, Kimberly Stegmaier

Annual Review of Cancer Biology

ChromatinSystems BiologyEwing SarcomaMalignant DiseaseOncogenic Agent +13

The ETS transcription factor ETV6 constrains the transcriptional activity of EWS–FLI to promote Ewing sarcoma

Diana Lu, Jana M. Ellegast, Kenneth N. Ross, +16

Nature Cell Biology

A Metastatic Mouse Model Identifies Genes That Regulate Neuroblastoma Metastasis

Bo Kyung A. Seong, Kelly E. Fathers, Robin Hallett, +7

Cancer Research

Neuro-oncologyTumor InnervationGliomaMetastatic SubpopulationsMedicine +11

Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules

Behnam Nabet, Fleur M. Ferguson, Bo Kyung A. Seong, +10

Degradation TagMolecular RegulationMolecular BiologyAntigen ProcessingProtein Homeostasis +16

Gene Fusions Create Partner and Collateral Dependencies Essential to Cancer Cell Survival

Riaz Gillani, Bo Kyung A. Seong, Jett Crowdis, +19

Cancer Research