Sofia Dust

CDK12 Inhibition Reverses De Novo and Acquired PARP Inhibitor Resistance in BRCA Wild-Type and Mutated Models of Triple-Negative Breast Cancer

Shawn F. Johnson, Cristina Cruz, Ann Katrin Greifenberg et al. · Cell Reports · 2016 · 286 citations · Full text

Medicine, Cancer Biology, Oncology +16

CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation

Małgorzata Krajewska, Ruben Dries, Andrew V. Grassetti et al. · Nature Communications · 2019 · 270 citations · Full text

Life Sciences, Genetics, Molecular Biology +13

Oncogenic <i>CDK13</i> mutations impede nuclear RNA surveillance

Megan L. Insco, Brian J. Abraham, Sara J. Dubbury et al. · Science · 2023 · 56 citations · Full text

Life Sciences, Molecular Biology, Oncology +15

Structure-activity relationship study of THZ531 derivatives enables the discovery of BSJ-01-175 as a dual CDK12/13 covalent inhibitor with efficacy in Ewing sarcoma

Baishan Jiang, Jie Jiang, Ines H. Kaltheuner et al. · European Journal of Medicinal Chemistry · 2021 · 51 citations · Full text

Medicine, Medicinal Chemistry, Oncology +11

CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation

Małgorzata Krajewska, Ruben Dries, Andrew V. Grassetti et al. · bioRxiv (Cold Spring Harbor Laboratory) · 2018 · 26 citations · Full text

Life Sciences, Genetics, Molecular Biology +13