Concepedia

CRISPR-Cas systems: Challenges and future prospects

Nisarg Gohil, Gargi Bhattacharjee, Navya L. Lam, Samuel D. Perli, Vijai Singh

Progress in molecular biology and translational science · 2021 · 31 citations · 46 references

DOI

Concepts

References

46

A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity

Martin Jínek, Krzysztof Chylinski, Ines Fonfara et al. · Science · 2012 · 17.3K citations · Full text

, , +17

Nucleic acid detection with CRISPR-Cas13a/C2c2

Jonathan S. Gootenberg, Omar O. Abudayyeh, Jeong Wook Lee et al. · Science · 2017 · 3.8K citations · Full text

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GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases

Shengdar Q. Tsai, Zongli Zheng, Nathalie T. Nguyen et al. · Nature Biotechnology · 2014 · 2.3K citations · Full text

, , +14

Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease

Seung Woo Cho, Sojung Kim, Jong Min Kim et al. · Nature Biotechnology · 2013 · 1.9K citations

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Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells

Van Trung Chu, Timm Weber, Benedikt Wefers et al. · Nature Biotechnology · 2015 · 1.2K citations

, , +14