Concepedia

A web tool for the design of prime-editing guide RNAs

Ryan D. Chow, Jennifer Chen, Johanna Shen, Sidi Chen

Nature Biomedical Engineering · 2020 · 164 citations · 13 references

DOIFull text

Open access

Concepts

References

13

A general method applicable to the search for similarities in the amino acid sequence of two proteins

Saul B. Needleman, Christian D. Wunsch · Journal of Molecular Biology · 1970 · 11.5K citations

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Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

John G. Doench, Nicolò Fusi, Meagan E. Sullender et al. · Nature Biotechnology · 2016 · 5K citations

, , +13

Search-and-replace genome editing without double-strand breaks or donor DNA

Andrew V. Anzalone, Peyton B. Randolph, Jessie R. Davis et al. · Nature · 2019 · 4.7K citations · Full text

, , +9

CHOPCHOP v3: expanding the CRISPR web toolbox beyond genome editing

Kornel Labun, Tessa G. Montague, Maximilian Krause et al. · Nucleic Acids Research · 2019 · 2.2K citations · Full text

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Evaluation of off-target and on-target scoring algorithms and integration into the guide RNA selection tool CRISPOR

Maximilian Haeussler, Kai Schönig, Hélène Eckert et al. · Genome biology · 2016 · 1.9K citations · Full text

, , +14