Evaluation of off-target and on-target scoring algorithms and integration into the guide RNA selection tool CRISPOR

Maximilian Haeussler, Kai Schönig, Hélène Eckert, +9

Genome biology

An efficient and versatile system for acute and chronic modulation of renal tubular function in transgenic mice

Milena Traykova-Brauch, Kai Schönig, Oliver Greiner, +13

Nature Medicine

UrologyXenotransplantationRenal FunctionMedicineKidney Failure +10

The Potential for β-Structure in the Repeat Domain of Tau Protein Determines Aggregation, Synaptic Decay, Neuronal Loss, and Coassembly with Endogenous Tau in Inducible Mouse Models of Tauopathy

Maria‐Magdalena Mocanu, Astrid Nissen, Katrin Eckermann, +10

Journal of Neuroscience

Stringent doxycycline dependent control of CRE recombinase in vivo

Kai Schönig

Nucleic Acids Research

The β-Propensity of Tau Determines Aggregation and Synaptic Loss in Inducible Mouse Models of Tauopathy

Katrin Eckermann, Maria‐Magdalena Mocanu, Inna Khlistunova, +10

Journal of Biological Chemistry

A progressive dopaminergic phenotype associated with neurotoxic conversion of α-synuclein in BAC-transgenic rats

Silke Nuber, Florian Harmuth, Zacharias Kohl, +18

Brain

NeurogenomicsSynaptic TransmissionMolecular BiologyNeurochemical BiomarkersBac-transgenic Rats +26

Defective glycosylation of coagulation factor XII underlies hereditary angioedema type III

Jenny Björkqvist, Steven de Maat, Urs Lewandrowski, +11

Journal of Clinical Investigation

Vascular DiseaseImmunologyPathologyInflammationThrombosis +16

Conditional Tetracycline–Regulated Expression of Tgf–β1 in Liver of Transgenic Mice Leads to Reversible Intermediary Fibrosis

Elke Ueberham, Rainer Löw, Uwe Ueberham, +3

Hepatology

Losing Control: Excessive Alcohol Seeking after Selective Inactivation of Cue-Responsive Neurons in the Infralimbic Cortex

Simone Pfarr, Marcus W. Meinhardt, M. L. Klee, +7

Journal of Neuroscience

Psilocybin targets a common molecular mechanism for cognitive impairment and increased craving in alcoholism

Marcus W. Meinhardt, Simone Pfarr, Grégory Fouquet, +19

Science Advances

NeuropsychologyBehavioral AddictionPsychopharmacologySocial SciencesPsychology +14