Early but not late conformational changes of tau in association with ubiquitination of neurofibrillary pathology in Alzheimer’s disease brains

The Consortium to Establish a Registry for Alzheimer's Disease (CERAD)

Suzanne S. Mirra, Albert Heyman, Daniel W. McKeel et al. · Neurology · 1991 · 5.1K citations

Medicine, Genetics, Neurology +17

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.

Inge Grundke‐Iqbal, Khurshid Iqbal, Y C Tung et al. · Proceedings of the National Academy of Sciences · 1986 · 3.6K citations · Full text

Life Sciences, Neurobiology, Neuroscience +15

Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease.

K S Kosik, Catharine Joachim, D. J. Selkoe · Proceedings of the National Academy of Sciences · 1986 · 1.5K citations

Life Sciences, Neurobiology, Neuroscience +16

Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau.

Michel Goedert, Claude M. Wischik, R. Anthony Crowther et al. · Proceedings of the National Academy of Sciences · 1988 · 1.1K citations · Full text

Life Sciences, Molecular Biology, Neurobiology +13

Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration

Brian R. Hoover, Miranda N. Reed, Jianjun Su et al. · Neuron · 2010 · 1.1K citations · Full text

Life Sciences, Neurobiology, Neuroscience +12