D. J. Selkoe

Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease.

K S Kosik, Catharine Joachim, D. J. Selkoe · Proceedings of the National Academy of Sciences · 1986 · 1.5K citations

Life Sciences, Neurobiology, Neuroscience +16

Beta-amyloid precursor protein of Alzheimer disease occurs as 110- to 135-kilodalton membrane-associated proteins in neural and nonneural tissues.

D. J. Selkoe, Marcia B. Podlisny, Catharine Joachim et al. · Proceedings of the National Academy of Sciences · 1988 · 578 citations · Full text

Life Sciences, Molecular Biology, Neuroscience +15

X-ray diffraction from intraneuronal paired helical filaments and extraneuronal amyloid fibers in Alzheimer disease indicates cross-beta conformation.

Daniel A. Kirschner, Carmela R. Abraham, D. J. Selkoe · Proceedings of the National Academy of Sciences · 1986 · 563 citations · Full text

Life Sciences, Biochemistry, Neuroscience +17

Excessive production of amyloid beta-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation.

Martin Citron, Carmen Vigo‐Pelfrey, David B. Teplow et al. · Proceedings of the National Academy of Sciences · 1994 · 368 citations · Full text

Medicine, Neurology, Pathology +12

Processing of beta-amyloid precursor protein in microglia and astrocytes favors an internal localization over constitutive secretion

Christian Haass, AY Hung, D. J. Selkoe · Journal of Neuroscience · 1991 · 280 citations · Full text

Medicine, Neurobiology, Neuroscience +13