Concepedia

Tau Conformation

Tau Conformation is a structural biology construct that specifies the three-dimensional folding state of the tau protein, distinguishing it by its pathogenic versus physiological isoforms in the context of neurodegenerative diseases.

534

Publications

56.3K

Citations

2.3K

Authors

708

Institutions

Publications per year

2017–2026

201

Parents

Publications

534

Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

Michel Goedert, Maria Grazia Spillantini, Ross Jakes et al. · Neuron · 1989 · 2.5K citations

, , +16

Cryo-EM structures of tau filaments from Alzheimer’s disease

Anthony W. P. Fitzpatrick, Benjamin Falcon, Shaoda He et al. · Nature · 2017 · 2.1K citations

, , +16

A68: a Major Subunit of Paired Helical Filaments and Derivatized Forms of Normal Tau

Virginia M.‐Y. Lee, Brian J. Balin, László Ötvös et al. · Science · 1991 · 1.4K citations

, , +17

Trans-Synaptic Spread of Tau Pathology In Vivo

Li Liu, Valérie Drouet, Jessica Wu et al. · PLoS ONE · 2012 · 1K citations · Full text

, , +16

Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease.

Claude M. Wischik, M Novák, Hans C. Thøgersen et al. · Proceedings of the National Academy of Sciences · 1988 · 944 citations · Full text

, , +14

1–5 of 534

Authors

2.3K

  1. EM
    Eckhard Mandelkow�

    Max Planck Unit for Structural Molecular Biology, Germany

    43 publications · 8K citations

    33

    h-index

  2. JB
    Jacek Biernat

    Max Planck Unit for Structural Molecular Biology, Germany

    23 publications · 4.6K citations

    23

    h-index

  3. MG
    Michel Goedert

    MRC Laboratory of Molecular Biology, United Kingdom

    20 publications · 9.3K citations

    18

    h-index

  4. MZ
    Markus Zweckstetter

    Max Planck Institute for Biophysical Chemistry, Germany

    17 publications · 2.8K citations

    17

    h-index

  5. LI
    Lester I. Binder

    Northwestern University, United States

    19 publications · 2.9K citations

    17

    h-index

1–5 of 2.3K

Institutions

708

  1. Centre National de la Recherche Scientifique

    Paris, France

    25 h-index

    119 publications

    10.1K citations

  2. German Center for Neurodegenerative Diseases

    Bonn, Germany

    24 h-index

    88 publications

    9.8K citations

  3. MRC Laboratory of Molecular Biology

    Cambridge, United Kingdom

    24 h-index

    132 publications

    69.5K citations

  4. University of Pennsylvania

    Philadelphia, United States

    22 h-index

    122 publications

    22.5K citations

  5. Max Planck Unit for Structural Molecular Biology

    Hamburg, Germany

    21 h-index

    97 publications

    22.3K citations

  6. Albert Einstein College of Medicine

    Bronx, United States

    18 h-index

    55 publications

    7.4K citations

  7. Center of Advanced European Studies and Research

    Bonn, Germany

    17 h-index

    37 publications

    3.8K citations

  8. Northwestern University

    Evanston, United States

    17 h-index

    74 publications

    11.1K citations

1–8 of 708

Venues

  1. Biochemistry

    37 publications · 4.3K citations

    34

    h-index

  2. Journal of Biological Chemistry

    JBC · 41 publications · 5K citations

    31

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 18 publications · 3.7K citations

    18

    h-index

  4. Journal of Alzheimer s Disease

    JAD · 20 publications · 1.2K citations

    16

    h-index

  5. Acta Neuropathologica

    14 publications · 1.8K citations

    14

    h-index

1–5