Concepedia

Reprogrammable CRISPR/dCas9-based recruitment of DNMT1 for site-specific DNA demethylation and gene regulation

Anrui Lu, Jingman Wang, Weihong Sun, Weiren Huang, Zhiming Cai, Guoping Zhao, Jin Wang

Cell Discovery · 2019 · 35 citations · 8 references

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References

8

Evolved Cas9 variants with broad PAM compatibility and high DNA specificity

Johnny H. Hu, Shannon M. Miller, Maarten H. Geurts et al. · Nature · 2018 · 1.6K citations

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DNMT1-interacting RNAs block gene-specific DNA methylation

Annalisa Di Ruscio, Alexander K. Ebralidze, Touati Benoukraf et al. · Nature · 2013 · 522 citations · Full text

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Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins

Morgan L. Maeder, James Angstman, Marcy E. Richardson et al. · Nature Biotechnology · 2013 · 506 citations · Full text

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Targeted DNA demethylation in vivo using dCas9–peptide repeat and scFv–TET1 catalytic domain fusions

Sumiyo Morita, Hirofumi Noguchi, Takuro Horii et al. · Nature Biotechnology · 2016 · 505 citations

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A CRISPR-based approach for targeted DNA demethylation

Xingxing Xu, Yonghui Tao, Xiaobo Gao et al. · Cell Discovery · 2016 · 384 citations · Full text

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