Rapamycin Corrects T Regulatory Cell Depletion and Improves Embryo Implantation and Live Birth Rates in a Murine Model

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

Randy Strong, Z. Dave Sharp, James F. Nelson et al. · Nature · 2009 · 3.7K citations · Full text

Lifespan Extension, Aging, Rapamycin Fed +11

The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage Commitment

Greg M. Delgoffe, Thomas P. Kole, Yan Zheng et al. · Immunity · 2009 · 1.2K citations · Full text

Signal Transduction, Cell Regulation, Signaling Pathway +9

The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2

Greg M. Delgoffe, Kristen Pollizzi, Adam T. Waickman et al. · Nature Immunology · 2011 · 1.1K citations · Full text

Kinase Mtor, Signal Transduction, Signaling Pathway +8

Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease

Katharina Lahl, Christoph Loddenkemper, Cathy E. Drouin et al. · The Journal of Experimental Medicine · 2007 · 905 citations · Full text

T-regulatory Cell, Immunology, Immune Regulation +18

T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR

Stephan Sauer, Ludovica Bruno, Arnulf Hertweck et al. · Proceedings of the National Academy of Sciences · 2008 · 821 citations · Full text

Immune Pathology, T-regulatory Cell, Immunology +22