E-pharmacophore-based screening of mGluR5 negative allosteric modulators for central nervous system disorder

Use of an Induced Fit Receptor Structure in Virtual Screening

Woody Sherman, Hege S. Beard, Ramy Farid · Chemical Biology & Drug Design · 2005 · 697 citations · Full text

Pharmacy, Bioinformatics, Medicinal Chemistry +17

Structure of a Class C GPCR Metabotropic Glutamate Receptor 1 Bound to an Allosteric Modulator

Huixian Wu, Chong Wang, Karen J. Gregory et al. · Science · 2014 · 547 citations

Life Sciences, Molecular Biology, Pharmacology +17

A Family of Highly Selective Allosteric Modulators of the Metabotropic Glutamate Receptor Subtype 5

Julie A. O’Brien, Wei Lemaire, Tsing‐Bau Chen et al. · Molecular Pharmacology · 2003 · 209 citations

Medicine, Medicinal Chemistry, Pharmacology +17

Mechanism of Assembly and Cooperativity of Homomeric and Heteromeric Metabotropic Glutamate Receptors

Joshua Levitz, Chris Habrian, Shashank Bharill et al. · Neuron · 2016 · 176 citations · Full text

Life Sciences, Molecular Biology, Neuroscience +12

Fragment and Structure-Based Drug Discovery for a Class C GPCR: Discovery of the mGlu ₅ Negative Allosteric Modulator HTL14242 (3-Chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile)

J.A. Christopher, Sarah J. Aves, K.A. Bennett et al. · Journal of Medicinal Chemistry · 2015 · 159 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17