Concepedia

Allosteric Modulator Screening

Allosteric Modulator Screening is a systematic experimental or computational method used in enzyme screening that identifies compounds capable of modulating enzyme activity by binding to allosteric sites, thereby distinguishing itself from orthosteric screening approaches through its focus on non-active site molecular interactions.

39

Publications

2.5K

Citations

372

Authors

88

Institutions

Publications per year

2017–2026

19

Parents

Publications

39

A Novel Positive Allosteric Modulator of the α7 Neuronal Nicotinic Acetylcholine Receptor:<i>In Vitro</i>and<i>In Vivo</i>Characterization

Raymond S Hurst, Mihály Hajós, M. Raggenbass et al. · Journal of Neuroscience · 2005 · 444 citations · Full text

, , +17

Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor

Jorge Fortanet, Christine Hiu-Tung Chen, Ying-Nan P. Chen et al. · Journal of Medicinal Chemistry · 2016 · 291 citations · Full text

, , +17

Discovery, Characterization, and Antiparkinsonian Effect of Novel Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4

Colleen M. Niswender, Kari A. Johnson, C. David Weaver et al. · Molecular Pharmacology · 2008 · 186 citations · Full text

, , +16

A new screening assay for allosteric inhibitors of cSrc

Jeffrey R. Simard, Sabine Klüter, Christian Grütter et al. · Nature Chemical Biology · 2009 · 125 citations · Full text

, , +14

AlloFinder: a strategy for allosteric modulator discovery and allosterome analyses

Min Huang, Kun Song, Xinyi Liu et al. · Nucleic Acids Research · 2018 · 91 citations · Full text

, , +14

1–5 of 39

Authors

372

  1. CW
    Craig W. Lindsley

    Vanderbilt University, United States

    10 publications · 632 citations

    10

    h-index

  2. PJ
    P. Jeffrey Conn

    Vanderbilt University, United States

    8 publications · 573 citations

    8

    h-index

  3. CM
    Colleen M. Niswender

    Vanderbilt University, United States

    7 publications · 494 citations

    7

    h-index

  4. CD
    C. David Weaver

    Vanderbilt University, United States

    4 publications · 301 citations

    4

    h-index

  5. PR
    Patrick R. Gentry

    Vanderbilt University, United States

    4 publications · 217 citations

    4

    h-index

1–5 of 372

Institutions

88

  1. Vanderbilt University

    Nashville, United States

    10 h-index

    74 publications

    3.7K citations

  2. Vanderbilt University Medical Center

    Nashville, United States

    7 h-index

    45 publications

    2.3K citations

  3. Zhengzhou University

    Zhengzhou, China

    2 h-index

    3 publications

    188 citations

  4. Bristol-Myers Squibb (United States)

    New York, United States

    2 h-index

    29 publications

    760 citations

  5. Janssen (Belgium)

    Beerse, Belgium

    2 h-index

    3 publications

    114 citations

  6. Shanghai Jiao Tong University

    Shanghai, China

    2 h-index

    27 publications

    2.2K citations

  7. Philadelphia University

    Philadelphia, United States

    1 h-index

    2 publications

    26 citations

  8. Second Military Medical University

    Shanghai, China

    1 h-index

    1 publications

    76 citations

1–8 of 88

Venues

  1. Journal of Medicinal Chemistry

    8 publications · 626 citations

    8

    h-index

  2. ACS Chemical Neuroscience

    3 publications · 156 citations

    3

    h-index

  3. Bioorganic & Medicinal Chemistry Letters

    2 publications · 96 citations

    2

    h-index

  4. 2

    h-index

  5. Nucleic Acids Research

    2 publications · 167 citations

    2

    h-index

1–5