Concepedia

Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition

Gabrielle S. Wong, Jin Zhou, Jie Bin Liu, Zhong Wu, Xinsen Xu, Tianxia Li, David Xu, Steven E. Schumacher, Jens Puschhof, James M. McFarland,

Nature Medicine · 2018 · 279 citations · 42 references

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42

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

Jordi Barretina, Giordano Caponigro, Nicolas Stransky et al. · Nature · 2012 · 8.5K citations

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Comprehensive molecular characterization of gastric adenocarcinoma

Adam J. Bass, Vésteinn Thórsson, David Van Den Berg et al. · Nature · 2014 · 6.5K citations · Full text

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Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases

Ying-Nan P. Chen, Matthew J. LaMarche, Ho Man Chan et al. · Nature · 2016 · 929 citations

, , +16

In vitro expansion and genetic modification of gastrointestinal stem cells in spheroid culture

Hiroyuki Miyoshi, Thaddeus S. Stappenbeck · Nature Protocols · 2013 · 793 citations · Full text

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Biochemical and Structural Analysis of Common Cancer-Associated KRAS Mutations

John C. Hunter, Anuj Manandhar, Martin A. Carrasco et al. · Molecular Cancer Research · 2015 · 782 citations

, , +17