James M. McFarland

Next-generation characterization of the Cancer Cell Line Encyclopedia

Mahmoud Ghandi, Franklin W. Huang, Judit Jané‐Valbuena et al. · Nature · 2019 · 3.5K citations · Full text

Tumor Heterogeneity, Medicine, Cancer Genomics +6

Computational correction of copy number effect improves specificity of CRISPR–Cas9 essentiality screens in cancer cells

Robin M. Meyers, Jordan Bryan, James M. McFarland et al. · Nature Genetics · 2017 · 2.1K citations · Full text

Genetics, Genetic Engineering, Crispr–cas9 Essentiality Screens +7

Discovering the anticancer potential of non-oncology drugs by systematic viability profiling

Steven M. Corsello, Rohith T. Nagari, Ryan D. Spangler et al. · Nature Cancer · 2020 · 831 citations · Full text

Tumor Biology, Systematic Viability Profiling, Medicine +12

Patient-derived xenografts undergo mouse-specific tumor evolution

Uri Ben‐David, Gavin Ha, Yuen‐Yi Tseng et al. · Nature Genetics · 2017 · 703 citations · Full text

Lineage Plasticity, Xenotransplantation, Tumor Heterogeneity +4

Mutational processes shape the landscape of TP53 mutations in human cancer

Andrew O. Giacomelli, Xiaoping Yang, Robert Lintner et al. · Nature Genetics · 2018 · 566 citations · Full text

Genome Instability, Somatic Variant, Tumor Heterogeneity +10