Genetic and transcriptional evolution alters cancer cell line drug response

Uri Ben‐David, Benjamin A. Siranosian, Gavin Ha, +27

Nature

Tumor HeterogeneityMedicineOncogenic AgentCancer GenomicsLine Drug Response +7

Discovering the anticancer potential of non-oncology drugs by systematic viability profiling

Steven M. Corsello, Rohith T. Nagari, Ryan D. Spangler, +35

Nature Cancer

Tumor BiologySystematic Viability ProfilingMedicineCancer ManagementPharmacology +10

Identification and Classification of Chromosomal Aberrations in Human Induced Pluripotent Stem Cells

Yoav Mayshar, Uri Ben‐David, Neta Lavon, +6

Cell stem cell

ChromatinInduced Pluripotent Stem CellMedicineGeneticsAdult Stem Cell +7

Patient-derived xenografts undergo mouse-specific tumor evolution

Uri Ben‐David, Gavin Ha, Yuen‐Yi Tseng, +8

Nature Genetics

Lineage PlasticityXenotransplantationTumor HeterogeneityMedicineRadiation Oncology +2

Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting

Andrew J. Aguirre, Robin M. Meyers, Barbara A. Weir, +27

Cancer Discovery

Selective Elimination of Human Pluripotent Stem Cells by an Oleate Synthesis Inhibitor Discovered in a High-Throughput Screen

Uri Ben‐David, Qing-Fen Gan, Tamar Golan‐Lev, +9

Cell stem cell

Induced Pluripotent Stem CellEngineeringMedicineAdult Stem CellHigh-throughput Screen +9

Cas9 activates the p53 pathway and selects for p53-inactivating mutations

Oana M. Enache, Verónica Rendo, Mai Abdusamad, +13

Nature Genetics

Tumor BiologyMedicineMolecular BiologyCancer GenomicsGenome Editing +6

Aneuploidy renders cancer cells vulnerable to mitotic checkpoint inhibition

Yael Cohen‐Sharir, James M. McFarland, Mai Abdusamad, +23

Nature

Genome InstabilityCell DivisionMedicineImmune Checkpoint InhibitorMitotic Checkpoint Inhibition +4

Large-Scale Analysis Reveals Acquisition of Lineage-Specific Chromosomal Aberrations in Human Adult Stem Cells

Uri Ben‐David, Yoav Mayshar, Nissim Benvenisty

Cell stem cell

ChromatinCell LineageDevelopmental BiologyLineage-specific Chromosomal AberrationsCell Specialization +10

Aneuploidy induces profound changes in gene expression, proliferation and tumorigenicity of human pluripotent stem cells

Uri Ben‐David, Gal Arad, Uri Weissbein, +8

Nature Communications

Induced Pluripotent Stem CellProfound ChangesMedicineGeneticsStem Cell Research +4