A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis

Yilong Zou, Michael J. Palte, Amy Deik, +17

Nature Communications

Patient-derived xenografts undergo mouse-specific tumor evolution

Uri Ben‐David, Gavin Ha, Yuen‐Yi Tseng, +8

Nature Genetics

Lineage PlasticityXenotransplantationTumor HeterogeneityMedicineRadiation Oncology +2

WRN helicase is a synthetic lethal target in microsatellite unstable cancers

Edmond M. Chan, Tsukasa Shibue, James M. McFarland, +38

Nature

Microsatellite Unstable CancersOncogenic AgentMedicineMolecular BiologyCancer Genomics +6

Genome-scale activation screen identifies a lncRNA locus regulating a gene neighbourhood

Julia Joung, J Engreitz, Silvana Konermann, +12

Nature

ChromatinGenome-scale Activation ScreenLncrna LocusGeneticsGene Regulation +7

Whole Exome Sequencing Identifies TSC1/TSC2 Biallelic Loss as the Primary and Sufficient Driver Event for Renal Angiomyolipoma Development

Krinio Giannikou, Izabela A. Malinowska, Trevor J. Pugh, +16

PLoS Genetics

UrologySomatic VariantRenal Angiomyolipoma DevelopmentTumor HeterogeneityRenal Angiomyolipoma +12

Assessment of heavy metal bioavailability in contaminated sediments and soils using green fluorescent protein-based bacterial biosensors

Vivian Hsiu‐Chuan Liao, Ming-Te Chien, Yuen‐Yi Tseng, +1

Environmental Pollution

Environmental ChemistryEngineeringMetal ContaminationEnvironmental RemediationHeavy Metal Bioavailability +6

CRISPR activation screen identifies BCL-2 proteins and B3GNT2 as drivers of cancer resistance to T cell-mediated cytotoxicity

Julia Joung, Paul C. Kirchgatterer, Ankita Singh, +8

Nature Communications

A Combination CDK4/6 and IGF1R Inhibitor Strategy for Ewing Sarcoma

Lillian M. Guenther, Neekesh V. Dharia, Linda S. Ross, +17

Clinical Cancer Research

Activation of endothelial cells to pathological status by down-regulation of connexin43

Hsueh-Hsiao Wang, Chang-I. Kung, Yuen‐Yi Tseng, +4

Cardiovascular Research

The PVT1-MYC duet in cancer

Yuen‐Yi Tseng, Anindya Bagchi

Molecular & Cellular Oncology

Hematological MalignancyFrequent MutationMedicineImmunologyMyc Protein +13