David Xu

Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition

Gabrielle S. Wong, Jin Zhou, Jie Bin Liu et al. · Nature Medicine · 2018 · 279 citations · Full text

Medicine, Cancer Biology, Oncology +11

Small-Molecule Covalent Modification of Conserved Cysteine Leads to Allosteric Inhibition of the TEAD⋅Yap Protein-Protein Interaction

Khuchtumur Bum‐Erdene, Donghui Zhou, Giovanni González-Gutiérrez et al. · Cell chemical biology · 2018 · 208 citations

Life Sciences, Biochemistry, Molecular Biology +17

Enzyme intermediates captured “on the fly” by mix-and-inject serial crystallography

J.L. Olmos, Suraj Pandey, José M. Martín-García et al. · BMC Biology · 2018 · 166 citations · Full text

Natural Sciences, Biochemistry, Chemistry +14

Targeted Therapies for Targeted Populations: Anti-EGFR Treatment for <i>EGFR</i> -Amplified Gastroesophageal Adenocarcinoma

Steven B. Maron, Lindsay Alpert, Heewon Kwak et al. · Cancer Discovery · 2018 · 121 citations · Full text

Medicine, Molecular Medicine, Oncology +17

RIG-I–like receptor LGP2 protects tumor cells from ionizing radiation

Ryan C. Widau, Akash D. Parekh, M.C. Ranck et al. · Proceedings of the National Academy of Sciences · 2014 · 90 citations · Full text

Medicine, Cancer Biology, Oncology +17