Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition

Gabrielle S. Wong, Jin Zhou, Jie Bin Liu, +34

Nature Medicine

Tumor BiologyOncologyEsophageal CancerGastrointestinal OncologyMedicine +7

Epidermal Growth Factor Receptor and Mutant p53 Expand an Esophageal Cellular Subpopulation Capable of Epithelial-to-Mesenchymal Transition through ZEB Transcription Factors

Shinya Ohashi, Mitsuteru Natsuizaka, Gabrielle S. Wong, +12

Cancer Research

Esophageal CancerPathologyCell ProliferationCancer BiologyTumor Biology +18

Isolation and characterization of mouse and human esophageal epithelial cells in 3D organotypic culture

Jiří Kalabis, Gabrielle S. Wong, Maria E. Vega, +5

Nature Protocols

Regenerative MedicineOrganotypic CultureDevelopmental BiologyEsophagusEsophageal Cancer +7

Hypoxia activates the cyclooxygenase-2–prostaglandin E synthase axis

James J. Lee, Mitsuteru Natsuizaka, Shinya Ohashi, +11

Carcinogenesis

Periostin, a Cell Adhesion Molecule, Facilitates Invasion in the Tumor Microenvironment and Annotates a Novel Tumor-Invasive Signature in Esophageal Cancer

Carmen Z. Michaylira, Gabrielle S. Wong, Charles G. Miller, +10

Cancer Research

Esophageal CancerCell Adhesion MoleculePathologyTumor BiologyOncology +15

Inducible deletion of epidermal <i>Dicer</i> and <i>Drosha</i> reveals multiple functions for miRNAs in postnatal skin

Monica Teta, Yeon Sook Choi, Tishina Okegbe, +8

Development

Postnatal SkinCell ProliferationDermatologyEpigeneticsStem Cell Loss +17

Insulin-like growth factor-binding protein-3 promotes transforming growth factor-β1-mediated epithelial-to-mesenchymal transition and motility in transformed human esophageal cells

Mitsuteru Natsuizaka, Shinya Ohashi, Gabrielle S. Wong, +7

Carcinogenesis

CDK4/6 or MAPK blockade enhances efficacy of EGFR inhibition in oesophageal squamous cell carcinoma

Jin Zhou, Zhong Wu, Gabrielle S. Wong, +14

Nature Communications

Periostin cooperates with mutant p53 to mediate invasion through the induction of STAT1 signaling in the esophageal tumor microenvironment

Gabrielle S. Wong, JS Lee, Y-Y Park, +7

Oncogenesis

Mutant P53Cancer ResearchEscc TumorsEscc DevelopmentMedicine +11

A common p53 mutation (R175H) activates c-Met receptor tyrosine kinase to enhance tumor cell invasion

Katharine D. Grugan, Maria E. Vega, Gabrielle S. Wong, +5

Cancer Biology & Therapy

PathologyC-met Receptor ActivationCommon P53 MutationCancer BiologyTumor Biology +14