Concepedia

Profilin 1–mediated cytoskeletal rearrangements regulate integrin function in mouse platelets

Simon Stritt, Inga Birkholz, Sarah Beck, Simona Sorrentino, K. Tanuj Sapra, Julien Viaud, Johannes Heck, Frédérique Gaits‐Iacovoni, Harald Schulze, Xiaoping Du,

Blood Advances · 2018 · 12 citations · 19 references

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Concepts

Abstract

Key Points Profilin 1–mediated cytoskeletal dynamics regulate platelet β1- and β3-integrin function and turnover. Profilin 1 deficiency in platelets impairs hemostasis and results in a marked protection from arterial thrombosis.

References

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