BIN1/M-Amphiphysin2 induces clustering of phosphoinositides to recruit its downstream partner dynamin

Laura Picas, Julien Viaud, Kristine Schauer, +10

Nature Communications

Signal TransductionBiochemistryNatural SciencesMechanism Of ActionMolecular Biology +7

An allosteric kinase inhibitor binds the p21-activated kinase autoregulatory domain covalently

Julien Viaud, Jeffrey R. Peterson

Molecular Cancer Therapeutics

Molecular PharmacologySignaling PathwayReceptor Tyrosine KinaseAnti-cancer AgentCell Signaling +15

Structure-based discovery of an inhibitor of Arf activation by Sec7 domains through targeting of protein–protein complexes

Julien Viaud, Mahel Zeghouf, Hélène Barelli, +7

Proceedings of the National Academy of Sciences

Molecular BiologySec7 DomainsProteomicsStructure-based DiscoveryExchange Reaction +15

Phosphatidylinositol 5-phosphate regulates invasion through binding and activation of Tiam1

Julien Viaud, Frédéric Lagarrigue, Damien Ramel, +8

Nature Communications

Signal TransductionSignaling PathwayMolecular RegulationMedicineNatural Sciences +8

The MTM1–UBQLN2–HSP complex mediates degradation of misfolded intermediate filaments in skeletal muscle

Christos Gavriilidis, Leila Laredj, Romain Solinhac, +5

Nature Cell Biology

Protein FunctionMolecular PhysiologyMuscle FunctionSkeletal MuscleProtein Folding +10

Structure-Based Design, Synthesis, and Biological Evaluation of Novel Inhibitors of Human Cyclophilin A

Jean‐François Guichou, Julien Viaud, Clément Mettling, +3

Journal of Medicinal Chemistry

Differences and similarities in the effects of ibrutinib and acalabrutinib on platelet functions

Jennifer Series, Cédric Garcia, M Levade, +4

Haematologica

Phosphoinositides Are Essential Coactivators for p21-Activated Kinase 1

Todd I. Strochlic, Julien Viaud, Ulrike Rennefahrt, +2

Molecular Cell

Signal TransductionSignaling PathwayP21-activated Kinase 1Cellular BiochemistryMedicine +3

Cdc42‐dependent F‐actin dynamics drive structuration of the demarcation membrane system in megakaryocytes

Adrien Antkowiak, Julien Viaud, Sonia Séverin, +9

Journal of Thrombosis and Haemostasis

Signal TransductionNatural SciencesMolecular BiologyCytoskeletonCell Motility +9

A dual role for the class III PI3K, Vps34, in platelet production and thrombus growth

Colin Valet, M Levade, Gaëtan Chicanne, +8

Blood