PKM2 is not required for colon cancer initiated by APC loss

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

Heather R. Christofk, Matthew G. Vander Heiden, Marian H. Harris et al. · Nature · 2008 · 2.8K citations

Tumor Biology, Medicine, Molecular Biology +9

Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

Weiwei Yang, Yan Xia, Haitao Ji et al. · Nature · 2011 · 1K citations · Full text

Nuclear Pkm2, Transcriptional Regulation, Signal Transduction +6

Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to antiEGFR treatment in colorectal cancer: a cohort study

Mauro Moroni, Silvio Veronese, Silvia Benvenuti et al. · The Lancet Oncology · 2005 · 948 citations

Cancer Epidemiology, Medicine, Pathology +9

PKM2 Phosphorylates Histone H3 and Promotes Gene Transcription and Tumorigenesis

Weiwei Yang, Yan Xia, David H. Hawke et al. · Cell · 2012 · 825 citations · Full text

Histone Modifications, Chromatin, Transcriptional Regulation +15

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

Dimitrios Anastasiou, Yimin Yu, William J. Israelsen et al. · Nature Chemical Biology · 2012 · 804 citations · Full text