Jatin Roper

Vitamin C selectively kills <i>KRAS</i> and <i>BRAF</i> mutant colorectal cancer cells by targeting GAPDH

Jihye Yun, Edouard Mullarky, Changyuan Lu et al. · Science · 2015 · 896 citations

WRN helicase is a synthetic lethal target in microsatellite unstable cancers

Edmond M. Chan, Tsukasa Shibue, James M. McFarland et al. · Nature · 2019 · 448 citations · Full text

Microsatellite Unstable Cancers, Oncogenic Agent, Medicine +8

Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis

René Jackstadt, Sander R. van Hooff, Joshua D.G. Leach et al. · Cancer Cell · 2019 · 433 citations · Full text

High-fructose corn syrup enhances intestinal tumor growth in mice

Marcus D. Goncalves, Changyuan Lu, Jordan Tutnauer et al. · Science · 2019 · 363 citations

Gastrointestinal Oncology, Medicine, High-fructose Corn Syrup +11

In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis

Jatin Roper, Tuomas Tammela, Naniye Mallı Cetinbas et al. · Nature Biotechnology · 2017 · 327 citations · Full text

Tumor Heterogeneity, Vivo Genome Editing, Medicine +9