Concepedia

Discovery of novel naphthoquinone derivatives as inhibitors of the tumor cell specific M2 isoform of pyruvate kinase

Xianling Ning, Hailong Qi, Ridong Li, Yunqiao Li, Yan Jin, Michael A. McNutt, Junyi Liu, Yuxin Yin

European Journal of Medicinal Chemistry · 2017 · 112 citations · 17 references

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17

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

Heather R. Christofk, Matthew G. Vander Heiden, Marian H. Harris et al. · Nature · 2008 · 2.8K citations

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Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

Weiwei Yang, Yan Xia, Haitao Ji et al. · Nature · 2011 · 1K citations · Full text

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Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

Dimitrios Anastasiou, Yimin Yu, William J. Israelsen et al. · Nature Chemical Biology · 2012 · 825 citations · Full text

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Pyruvate Kinase M2 Regulates Gene Transcription by Acting as a Protein Kinase

Xueliang Gao, Haizhen Wang, Jenny Yang et al. · Molecular Cell · 2012 · 767 citations · Full text

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Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2

J Chen, Jiaxin Xie, Zhinong Jiang et al. · Oncogene · 2011 · 516 citations

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