Concepedia

Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2

J Chen, Jiaxin Xie, Zhinong Jiang, B Wang, Yuxi Wang, Xun Hu

Oncogene · 2011 · 516 citations · 33 references

DOI

Concepts

References

33

On the Origin of Cancer Cells

Otto Warbürg · Science · 1956 · 13.3K citations

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Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury

Alexei Degterev, Zhihong Huang, Michael Boyce et al. · Nature Chemical Biology · 2005 · 3K citations

, , +17

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

Heather R. Christofk, Matthew G. Vander Heiden, Marian H. Harris et al. · Nature · 2008 · 2.8K citations

, , +16

Cancer Cell Metabolism: Warburg and Beyond

Peggy P. Hsu, David M. Sabatini · Cell · 2008 · 2.5K citations · Full text

, , +12

Identification of RIP1 kinase as a specific cellular target of necrostatins

Alexei Degterev, Junichi Hitomi, Megan Germscheid et al. · Nature Chemical Biology · 2008 · 2K citations · Full text

, , +14