Vasopressin and Bradykinin Regulate Secretory Processing of the Amyloid Protein Precursor of Alzheimer's Disease

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

Alison Goate, Marie‐Christine Chartier‐Harlin, Jeremy Brown et al. · Nature · 1991 · 4.6K citations

Life Sciences, Genetics, Molecular Genetics +16

Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

Donalyn Scheuner, Christopher B. Eckman, M. Jensen et al. · Nature Medicine · 1996 · 2.6K citations

Life Sciences, Neurobiology, Neuroscience +16

Role of poly(ADP-ribose) formation in DNA repair

Masahiko S. Satoh, Tomas Lindahl · Nature · 1992 · 1.2K citations

Life Sciences, Biochemistry, Molecular Biology +11

Release of Alzheimer Amyloid Precursor Derivatives Stimulated by Activation of Muscarinic Acetylcholine Receptors

Roger M. Nitsch, Barbara E. Slack, Richard J. Wurtman et al. · Science · 1992 · 899 citations

Life Sciences, Neurobiology, Neuroscience +17

Evidence that β-Amyloid Protein in Alzheimer's Disease Is Not Derived by Normal Processing

Sangram S. Sisodia, Edward H. Koo, Konrad Beyreuther et al. · Science · 1990 · 891 citations

Life Sciences, Biochemistry, Molecular Biology +17