Nature Biotechnology · 2017 · 281 citations · 24 references
Life SciencesMolecular BiologyMolecular GeneticsGenome EditingGenome EngineeringGenomicsCrispr-cas SystemsGuide Rna DesignOff-target EffectsRna EditingRna EngineeringTarget Site SelectionCas Nuclease SpecificityCrispr Guide Rna DesignCrispr-cas Target CleavageDeaminase EngineeringRna Targeting
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Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
Alexis C. Komor, Y. Bill Kim, Michael S. Packer et al. · Nature · 2016 · 5.4K citations · Full text
In vivo genome editing using Staphylococcus aureus Cas9
F. Ann Ran, Le Cong, Winston X. Yan et al. · Nature · 2015 · 2.7K citations · Full text
High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects
Benjamin P. Kleinstiver, Vikram Pattanayak, Michelle S. Prew et al. · Nature · 2016 · 2.7K citations · Full text
Rationally engineered Cas9 nucleases with improved specificity
Ian M. Slaymaker, Linyi Gao, Bernd Zetsche et al. · Science · 2015 · 2.5K citations