Concepedia

Local Delivery of PHD2 siRNA from ROS‐Degradable Scaffolds to Promote Diabetic Wound Healing

John R. Martin, Christopher E. Nelson, Mukesh Kumar Gupta, Fang Yu, Samantha M. Sarett, Kyle M. Hocking, Alonda C. Pollins, Lillian B. Nanney, Jeffrey M. Davidson, Scott A. Guelcher,

Advanced Healthcare Materials · 2016 · 89 citations · 48 references

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Abstract

Small interfering RNA (siRNA) delivered from reactive oxygen species-degradable tissue engineering scaffolds promotes diabetic wound healing in rats. Porous poly(thioketal-urethane) scaffolds implanted in diabetic wounds locally deliver siRNA that inhibits the expression of prolyl hydroxylase domain protein 2, thereby increasing the expression of progrowth genes and increasing vasculature, proliferating cells, and tissue development in diabetic wounds.

References

48

Activation of Vascular Endothelial Growth Factor Gene Transcription by Hypoxia-Inducible Factor 1

Jo A. Forsythe, Bing‐Hua Jiang, Narayan V. Iyer et al. · Molecular and Cellular Biology · 1996 · 3.9K citations · Full text

C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation

Andrew Epstein, Jonathan Gleadle, Luke A. McNeill et al. · Cell · 2001 · 3.3K citations · Full text

, , +11

Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1

Daniel J. Ceradini, Anita R. Kulkarni, Matthew J. Callaghan et al. · Nature Medicine · 2004 · 2.6K citations

, , +11

HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1  in normoxia

Edurne Berra · The EMBO Journal · 2003 · 1.3K citations · Full text

, , +9

Identification and characterization of a fibroblast marker: FSP1.

Frank Strutz, Hirokazu Okada, Clement Lo et al. · The Journal of Cell Biology · 1995 · 1.1K citations

, , +13